STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLA2G5Phospholipase A(2). (158 aa)    
Predicted Functional Partners:
PLA2G3
Phospholipase A2 group III.
     
 0.827
W5NXJ5_SHEEP
LRAT domain-containing protein.
     
 0.803
PLAAT3
LRAT domain-containing protein.
     
 0.803
PLA2G15
Uncharacterized protein.
     
 0.787
PTGS1
Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
     
 0.750
PAFAH2
Platelet-activating factor acetylhydrolase.
     
 0.744
PLA2G4A
Phospholipase A2.
     
 0.744
PAFAH1B2
Platelet activating factor acetylhydrolase 1b catalytic subunit 2.
     
 0.737
NCR3
Natural cytotoxicity triggering receptor 3.
   
  
 0.722
PLA2G4F
Phospholipase A2.
     
 0.704
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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