W5NSC5_SHEEP protein (Ovis aries) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

W5NSC5_SHEEP

CUE domain-containing protein. (280 aa)

Predicted Functional Partners:

IRAK4

0.908

IRAK1

0.901

MYD88

0.869

TOM1

0.826

TLR4

0.781

TOM1-2

0.761

TRAF6

0.736

IRAK2

0.723

IL1B

0.696

SIGIRR

0.691

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL1B	IRAK1	ENSOARP00000022427	ENSOARP00000006297	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Interleukin 1 receptor associated kinase 1.	0.821
IL1B	IRAK2	ENSOARP00000022427	ENSOARP00000005327	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Interleukin 1 receptor associated kinase 2.	0.646
IL1B	IRAK4	ENSOARP00000022427	ENSOARP00000021135	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Protein kinase domain-containing protein.	0.830
IL1B	MYD88	ENSOARP00000022427	ENSOARP00000001070	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.947
IL1B	TLR4	ENSOARP00000022427	ENSOARP00000006210	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.955
IL1B	TRAF6	ENSOARP00000022427	ENSOARP00000020492	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.886
IL1B	W5NSC5_SHEEP	ENSOARP00000022427	ENSOARP00000001065	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	CUE domain-containing protein.	0.696
IRAK1	IL1B	ENSOARP00000006297	ENSOARP00000022427	Interleukin 1 receptor associated kinase 1.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.821
IRAK1	IRAK2	ENSOARP00000006297	ENSOARP00000005327	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 2.	0.991
IRAK1	IRAK4	ENSOARP00000006297	ENSOARP00000021135	Interleukin 1 receptor associated kinase 1.	Protein kinase domain-containing protein.	0.999
IRAK1	MYD88	ENSOARP00000006297	ENSOARP00000001070	Interleukin 1 receptor associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.999
IRAK1	SIGIRR	ENSOARP00000006297	ENSOARP00000008023	Interleukin 1 receptor associated kinase 1.	Single Ig and TIR domain containing.	0.648
IRAK1	TLR4	ENSOARP00000006297	ENSOARP00000006210	Interleukin 1 receptor associated kinase 1.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.939
IRAK1	TRAF6	ENSOARP00000006297	ENSOARP00000020492	Interleukin 1 receptor associated kinase 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
IRAK1	W5NSC5_SHEEP	ENSOARP00000006297	ENSOARP00000001065	Interleukin 1 receptor associated kinase 1.	CUE domain-containing protein.	0.901
IRAK2	IL1B	ENSOARP00000005327	ENSOARP00000022427	Interleukin 1 receptor associated kinase 2.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.646
IRAK2	IRAK1	ENSOARP00000005327	ENSOARP00000006297	Interleukin 1 receptor associated kinase 2.	Interleukin 1 receptor associated kinase 1.	0.991
IRAK2	IRAK4	ENSOARP00000005327	ENSOARP00000021135	Interleukin 1 receptor associated kinase 2.	Protein kinase domain-containing protein.	0.999
IRAK2	MYD88	ENSOARP00000005327	ENSOARP00000001070	Interleukin 1 receptor associated kinase 2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.984
IRAK2	SIGIRR	ENSOARP00000005327	ENSOARP00000008023	Interleukin 1 receptor associated kinase 2.	Single Ig and TIR domain containing.	0.501