STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ITIH3Inter-alpha-trypsin inhibitor heavy chain 3. (891 aa)    
Predicted Functional Partners:
AMBP
Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.
   
  
 0.837
C8A
Complement C8 alpha chain.
   
 0.677
FGL1
Fibrinogen like 1.
   
 
 0.670
APOH
Apolipoprotein H.
   
 0.616
ITIH5
Inter-alpha-trypsin inhibitor heavy chain 5.
 
0.612
TXNDC8
Thioredoxin domain containing 8.
    
 
 0.606
SERPIND1
Serpin family D member 1; Belongs to the serpin family.
   
 
 0.603
MYOM3
Myomesin 3.
   
 0.590
AHSG
Alpha-2-HS-glycoprotein; Belongs to the fetuin family.
   
 0.589
FKBP1B
Peptidylprolyl isomerase.
    
 0.583
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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