STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRAF2-2MATH domain-containing protein. (215 aa)    
Predicted Functional Partners:
TRADD
TNFRSF1A associated via death domain.
    
 0.994
BIRC3
Baculoviral IAP repeat containing 3.
   
 0.992
FADD
FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
   
 0.989
BIRC2
Baculoviral IAP repeat containing 2.
   
 0.988
MAVS
Mitochondrial antiviral signaling protein.
    
 0.983
TRAF1
TNF receptor-associated factor.
  
  
0.981
TNFRSF1A
Uncharacterized protein.
    
 0.979
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
   
 0.978
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 0.977
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
 0.976
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.