NPC2 protein (Ovis aries) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

NPC2

NPC intracellular cholesterol transporter 2. (149 aa)

Predicted Functional Partners:

NPC1-2

0.999

NPC1

0.990

NPC1L1

0.901

SCAP

0.790

APOB

0.626

CD52

0.583

ATP7B

0.558

GM2A

0.556

LAMP1

0.527

CCT7

0.502

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOB	NPC1L1	ENSOARP00000018682	ENSOARP00000016610	Apolipoprotein B.	NPC1 like intracellular cholesterol transporter 1.	0.586
APOB	NPC2	ENSOARP00000018682	ENSOARP00000001118	Apolipoprotein B.	NPC intracellular cholesterol transporter 2.	0.626
ATP7B	NPC1	ENSOARP00000009727	ENSOARP00000008490	Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.	NPC intracellular cholesterol transporter 1.	0.487
ATP7B	NPC1-2	ENSOARP00000009727	ENSOARP00000000816	Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.	SSD domain-containing protein.	0.487
ATP7B	NPC2	ENSOARP00000009727	ENSOARP00000001118	Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.	NPC intracellular cholesterol transporter 2.	0.558
CCT7	NPC2	ENSOARP00000012677	ENSOARP00000001118	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	NPC intracellular cholesterol transporter 2.	0.502
CD52	NPC2	ENSOARP00000005150	ENSOARP00000001118	Uncharacterized protein.	NPC intracellular cholesterol transporter 2.	0.583
GM2A	NPC2	ENSOARP00000009048	ENSOARP00000001118	GM2 ganglioside activator.	NPC intracellular cholesterol transporter 2.	0.556
LAMP1	NPC1	ENSOARP00000008813	ENSOARP00000008490	Lysosomal associated membrane protein 1.	NPC intracellular cholesterol transporter 1.	0.670
LAMP1	NPC1-2	ENSOARP00000008813	ENSOARP00000000816	Lysosomal associated membrane protein 1.	SSD domain-containing protein.	0.686
LAMP1	NPC2	ENSOARP00000008813	ENSOARP00000001118	Lysosomal associated membrane protein 1.	NPC intracellular cholesterol transporter 2.	0.527
NPC1	ATP7B	ENSOARP00000008490	ENSOARP00000009727	NPC intracellular cholesterol transporter 1.	Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.	0.487
NPC1	LAMP1	ENSOARP00000008490	ENSOARP00000008813	NPC intracellular cholesterol transporter 1.	Lysosomal associated membrane protein 1.	0.670
NPC1	NPC2	ENSOARP00000008490	ENSOARP00000001118	NPC intracellular cholesterol transporter 1.	NPC intracellular cholesterol transporter 2.	0.990
NPC1-2	ATP7B	ENSOARP00000000816	ENSOARP00000009727	SSD domain-containing protein.	Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.	0.487
NPC1-2	LAMP1	ENSOARP00000000816	ENSOARP00000008813	SSD domain-containing protein.	Lysosomal associated membrane protein 1.	0.686
NPC1-2	NPC2	ENSOARP00000000816	ENSOARP00000001118	SSD domain-containing protein.	NPC intracellular cholesterol transporter 2.	0.999
NPC1L1	APOB	ENSOARP00000016610	ENSOARP00000018682	NPC1 like intracellular cholesterol transporter 1.	Apolipoprotein B.	0.586
NPC1L1	NPC2	ENSOARP00000016610	ENSOARP00000001118	NPC1 like intracellular cholesterol transporter 1.	NPC intracellular cholesterol transporter 2.	0.901
NPC2	APOB	ENSOARP00000001118	ENSOARP00000018682	NPC intracellular cholesterol transporter 2.	Apolipoprotein B.	0.626