STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF319Zinc finger protein 319. (582 aa)    
Predicted Functional Partners:
RNF149
RING-type domain-containing protein.
    
 
 0.700
ZNF207
Zinc finger protein 207.
      
 0.613
UBA2
SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.
    
 0.599
JOSD1
Josephin domain containing 1.
      
 0.587
KIAA0040
KIAA0040.
      
 0.581
UBE2O
Ubiquitin conjugating enzyme E2 O.
    
 0.580
UBE2Z
Ubiquitin conjugating enzyme E2 Z.
    
 0.579
RNF25
Ring finger protein 25.
      
 0.568
HUWE1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
    
 
 0.555
SPNS3
Sphingolipid transporter 3 (putative).
    
 
 0.540
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.