HYAL4 protein (Ovis aries) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

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[Homology]

Score

HYAL4

Hyaluronidase. (481 aa)

Predicted Functional Partners:

GUSB

0.927

ARSB

0.913

CD44

0.866

ITSN2

0.833

ALB

0.780

ITSN1

0.742

CD4

0.725

HAS2

0.697

HAS1

0.665

GAK

0.652

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CD4	ENSOARP00000014782	ENSOARP00000006749	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.974
ALB	CD44	ENSOARP00000014782	ENSOARP00000020204	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	CD44 molecule (Indian blood group).	0.813
ALB	GUSB	ENSOARP00000014782	ENSOARP00000001651	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Glyco_hydro_2_C domain-containing protein.	0.489
ALB	HYAL4	ENSOARP00000014782	ENSOARP00000001162	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	Hyaluronidase.	0.780
ARSB	GUSB	ENSOARP00000018422	ENSOARP00000001651	Arylsulfatase B.	Glyco_hydro_2_C domain-containing protein.	0.488
ARSB	HYAL4	ENSOARP00000018422	ENSOARP00000001162	Arylsulfatase B.	Hyaluronidase.	0.913
CD4	ALB	ENSOARP00000006749	ENSOARP00000014782	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.974
CD4	CD44	ENSOARP00000006749	ENSOARP00000020204	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	CD44 molecule (Indian blood group).	0.973
CD4	HYAL4	ENSOARP00000006749	ENSOARP00000001162	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Hyaluronidase.	0.725
CD44	ALB	ENSOARP00000020204	ENSOARP00000014782	CD44 molecule (Indian blood group).	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.813
CD44	CD4	ENSOARP00000020204	ENSOARP00000006749	CD44 molecule (Indian blood group).	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.973
CD44	HAS1	ENSOARP00000020204	ENSOARP00000016021	CD44 molecule (Indian blood group).	Hyaluronan synthase 1.	0.541
CD44	HAS2	ENSOARP00000020204	ENSOARP00000011850	CD44 molecule (Indian blood group).	Hyaluronan synthase 2.	0.765
CD44	HYAL4	ENSOARP00000020204	ENSOARP00000001162	CD44 molecule (Indian blood group).	Hyaluronidase.	0.866
GAK	HYAL4	ENSOARP00000017570	ENSOARP00000001162	Cyclin G associated kinase.	Hyaluronidase.	0.652
GAK	ITSN1	ENSOARP00000017570	ENSOARP00000013825	Cyclin G associated kinase.	Intersectin 1.	0.616
GAK	ITSN2	ENSOARP00000017570	ENSOARP00000019246	Cyclin G associated kinase.	Intersectin 2.	0.710
GUSB	ALB	ENSOARP00000001651	ENSOARP00000014782	Glyco_hydro_2_C domain-containing protein.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]	0.489
GUSB	ARSB	ENSOARP00000001651	ENSOARP00000018422	Glyco_hydro_2_C domain-containing protein.	Arylsulfatase B.	0.488
GUSB	HYAL4	ENSOARP00000001651	ENSOARP00000001162	Glyco_hydro_2_C domain-containing protein.	Hyaluronidase.	0.927