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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5NSM8_SHEEPUncharacterized protein. (617 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta 1.
    
 0.616
JUP
Junction plakoglobin.
    
 0.616
ARFGEF2
ADP ribosylation factor guanine nucleotide exchange factor 2.
   
  
 0.542
MOB2
Uncharacterized protein.
   
  
 0.540
CDHR5
Cadherin related family member 5.
   
 0.508
PCDH15
Protocadherin related 15.
   
0.508
W5P257_SHEEP
WD_REPEATS_REGION domain-containing protein.
      
 0.480
PRR13
Proline rich 13.
    
 
 0.466
TCTN2
Tectonic family member 2.
    
 
 0.435
PTPN14
Protein tyrosine phosphatase non-receptor type 14.
    
 0.435
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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