STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (505 aa)    
Predicted Functional Partners:
CHRNA5
Cholinergic receptor nicotinic alpha 5 subunit.
  
0.966
CHRNB4
Cholinergic receptor nicotinic beta 4 subunit.
  
  
0.958
SLURP1
UPAR/Ly6 domain-containing protein.
     
 0.907
JAK2
Tyrosine-protein kinase.
    
  0.901
CHRNB2
Cholinergic receptor nicotinic beta 2 subunit.
  
  
0.873
CHRNA1
Cholinergic receptor nicotinic alpha 1 subunit.
  
0.856
CHRNA4
Cholinergic receptor nicotinic alpha 4 subunit.
  
0.822
W5NPM0_SHEEP
Uncharacterized protein.
  
0.775
CHRNA2
Cholinergic receptor nicotinic alpha 2 subunit.
  
0.693
CHRM2
Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
      
 0.687
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.