HFE protein (Ovis aries) - STRING interaction network

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[Homology]

Score

HFE

Homeostatic iron regulator; Belongs to the MHC class I family. (335 aa)

Predicted Functional Partners:

TFRC

0.999

TFR2

0.998

HJV

0.986

HAMP

0.922

B2M

0.809

RPA2

0.765

EPO

0.760

TMPRSS6

0.745

SLC40A1

0.677

BMP6

0.640

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	EPO	ENSOARP00000004039	ENSOARP00000017231	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	0.402
B2M	HFE	ENSOARP00000004039	ENSOARP00000001193	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Homeostatic iron regulator; Belongs to the MHC class I family.	0.809
B2M	TFR2	ENSOARP00000004039	ENSOARP00000017672	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Transferrin receptor 2.	0.432
B2M	TFRC	ENSOARP00000004039	ENSOARP00000021809	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Transferrin receptor.	0.761
BMP6	EPO	ENSOARP00000018529	ENSOARP00000017231	Bone morphogenetic protein 6.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	0.421
BMP6	HAMP	ENSOARP00000018529	ENSOARP00000005089	Bone morphogenetic protein 6.	Hepcidin.	0.722
BMP6	HFE	ENSOARP00000018529	ENSOARP00000001193	Bone morphogenetic protein 6.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.640
BMP6	HJV	ENSOARP00000018529	ENSOARP00000022202	Bone morphogenetic protein 6.	Hemojuvelin BMP co-receptor.	0.726
BMP6	TFR2	ENSOARP00000018529	ENSOARP00000017672	Bone morphogenetic protein 6.	Transferrin receptor 2.	0.627
BMP6	TMPRSS6	ENSOARP00000018529	ENSOARP00000020617	Bone morphogenetic protein 6.	Transmembrane serine protease 6; Belongs to the peptidase S1 family.	0.596
EPO	B2M	ENSOARP00000017231	ENSOARP00000004039	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	0.402
EPO	BMP6	ENSOARP00000017231	ENSOARP00000018529	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Bone morphogenetic protein 6.	0.421
EPO	HAMP	ENSOARP00000017231	ENSOARP00000005089	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Hepcidin.	0.620
EPO	HFE	ENSOARP00000017231	ENSOARP00000001193	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.760
EPO	RPA2	ENSOARP00000017231	ENSOARP00000003452	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Replication protein A2.	0.402
EPO	TFRC	ENSOARP00000017231	ENSOARP00000021809	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Transferrin receptor.	0.467
HAMP	BMP6	ENSOARP00000005089	ENSOARP00000018529	Hepcidin.	Bone morphogenetic protein 6.	0.722
HAMP	EPO	ENSOARP00000005089	ENSOARP00000017231	Hepcidin.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	0.620
HAMP	HFE	ENSOARP00000005089	ENSOARP00000001193	Hepcidin.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.922
HAMP	HJV	ENSOARP00000005089	ENSOARP00000022202	Hepcidin.	Hemojuvelin BMP co-receptor.	0.829