LAT protein (Ovis aries) - STRING interaction network

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[Homology]

Score

LAT

Linker for activation of T cells. (258 aa)

Predicted Functional Partners:

PLCG1

0.999

ZAP70

0.999

GRB2

0.998

GRAP2

0.998

SYK

0.997

CD3E

0.996

PLCG2

0.995

LCP2

0.994

PIK3R1

0.985

LAT2

0.962

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD3E	GRAP2	ENSOARP00000009648	ENSOARP00000018360	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	GRB2 related adaptor protein 2.	0.525
CD3E	LAT	ENSOARP00000009648	ENSOARP00000001199	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Linker for activation of T cells.	0.996
CD3E	LCP2	ENSOARP00000009648	ENSOARP00000003379	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Lymphocyte cytosolic protein 2.	0.603
CD3E	PIK3R1	ENSOARP00000009648	ENSOARP00000006294	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Phosphoinositide-3-kinase regulatory subunit 1.	0.593
CD3E	PLCG1	ENSOARP00000009648	ENSOARP00000001796	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.410
CD3E	SYK	ENSOARP00000009648	ENSOARP00000008390	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.935
CD3E	ZAP70	ENSOARP00000009648	ENSOARP00000014636	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.999
GRAP2	CD3E	ENSOARP00000018360	ENSOARP00000009648	GRB2 related adaptor protein 2.	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.525
GRAP2	GRB2	ENSOARP00000018360	ENSOARP00000011400	GRB2 related adaptor protein 2.	Growth factor receptor bound protein 2.	0.696
GRAP2	LAT	ENSOARP00000018360	ENSOARP00000001199	GRB2 related adaptor protein 2.	Linker for activation of T cells.	0.998
GRAP2	LAT2	ENSOARP00000018360	ENSOARP00000012695	GRB2 related adaptor protein 2.	Linker for activation of T cells family member 2.	0.521
GRAP2	LCP2	ENSOARP00000018360	ENSOARP00000003379	GRB2 related adaptor protein 2.	Lymphocyte cytosolic protein 2.	0.999
GRAP2	PIK3R1	ENSOARP00000018360	ENSOARP00000006294	GRB2 related adaptor protein 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.576
GRAP2	PLCG1	ENSOARP00000018360	ENSOARP00000001796	GRB2 related adaptor protein 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.877
GRAP2	PLCG2	ENSOARP00000018360	ENSOARP00000009666	GRB2 related adaptor protein 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.919
GRAP2	SYK	ENSOARP00000018360	ENSOARP00000008390	GRB2 related adaptor protein 2.	Tyrosine-protein kinase.	0.649
GRAP2	ZAP70	ENSOARP00000018360	ENSOARP00000014636	GRB2 related adaptor protein 2.	Tyrosine-protein kinase.	0.763
GRB2	GRAP2	ENSOARP00000011400	ENSOARP00000018360	Growth factor receptor bound protein 2.	GRB2 related adaptor protein 2.	0.696
GRB2	LAT	ENSOARP00000011400	ENSOARP00000001199	Growth factor receptor bound protein 2.	Linker for activation of T cells.	0.998
GRB2	LAT2	ENSOARP00000011400	ENSOARP00000012695	Growth factor receptor bound protein 2.	Linker for activation of T cells family member 2.	0.985