Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-expression
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[Homology]
Score
COX4I2Cytochrome c oxidase subunit 4I2. (171 aa)    
Predicted Functional Partners:
COX5A
Cytochrome c oxidase subunit 5A.
   
 0.996
COX5B
Cytochrome c oxidase subunit 5B.
   
 0.994
COX6B2
Cytochrome c oxidase subunit 6B2.
   
 0.982
UQCRB
Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family.
   
 0.981
COX6A2
Cytochrome c oxidase subunit 6A, mitochondrial.
   
 0.980
UQCRC2
Ubiquinol-cytochrome c reductase core protein 2; Belongs to the peptidase M16 family.
   
 0.979
COX8A
Cytochrome c oxidase subunit 8A.
   
 0.977
UQCRQ
Ubiquinol-cytochrome c reductase complex III subunit VII.
   
 0.977
COX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...]
   
 0.976
W5P473_SHEEP
Uncharacterized protein.
   
 0.975
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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