Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CYP4F21Uncharacterized protein; Belongs to the cytochrome P450 family. (411 aa)    
Predicted Functional Partners:
VSIG1
V-set and immunoglobulin domain containing 1.
    
 
 0.835
ADAM11
ADAM metallopeptidase domain 11.
   
  
 0.803
PRND
Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family.
   
  
 0.768
SLC4A5
Anion exchange protein.
      
 0.758
FATE1
Miff domain-containing protein.
      
 0.696
W5P826_SHEEP
Cystatin domain-containing protein.
      
 0.671
MAGEA10
MAGE family member A10.
      
 0.589
MAGEB18
MAGE family member B18.
      
 0.588
W5P6V8_SHEEP
Uncharacterized protein; Belongs to the cytochrome P450 family.
  
 0.578
CACNG4
Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
      
 0.541
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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