STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AREL1Apoptosis resistant E3 ubiquitin protein ligase 1. (923 aa)    
Predicted Functional Partners:
TRIP12
Thyroid hormone receptor interactor 12.
   
 
0.711
YLPM1
YLP motif containing 1.
   
  
 0.626
COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
      
 0.624
FAM161B
FAM161 centrosomal protein B.
      
 0.613
PROX2
Prospero homeobox 2.
      
 0.613
LRRC74A
Leucine rich repeat containing 74A.
      
 0.613
FCF1
PINc domain-containing protein.
      
 0.609
FAU
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 0.606
ABCD4
ATP binding cassette subfamily D member 4.
    
 
 0.597
HEATR4
HEAT repeat containing 4.
      
 0.588
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.