Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LOC101112427CAP18_C domain-containing protein. (175 aa)    
Predicted Functional Partners:
NFKB1
Nuclear factor kappa B subunit 1.
   
 
 0.909
RELA
RELA proto-oncogene, NF-kB subunit.
   
 
 0.905
CATHL2
Cathelicidin-2; Binds to the lipid A moiety of bacterial lipipolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Potent antimicrobial activity (By similarity); Belongs to the cathelicidin family.
   
    0.882
W5P1Y8_SHEEP
Uncharacterized protein.
   
 
  0.809
PGLYRP1
Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity.
   
  
 0.690
HMGB2
Uncharacterized protein.
      
 0.570
S100A8
S100 calcium binding protein A8; Belongs to the S-100 family.
   
  
 0.548
LCN2
Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.539
W5NUU0_SHEEP
Uncharacterized protein.
   
 
  0.532
SC52_SHEEP
Cathelin-related peptide SC5; Broad spectrum bactericidal agent.
   
 
  0.532
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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