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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCDH1Protocadherin 1. (1265 aa)    
Predicted Functional Partners:
W5QG06_SHEEP
Uncharacterized protein.
     
 0.617
PCDH8
Uncharacterized protein.
 
    
 0.612
MPDZ
Multiple PDZ domain crumbs cell polarity complex component.
    
 
 0.511
LIN7A
Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.
      
 0.511
CTNNA1
Catenin alpha 1.
    
 0.508
W5NPD8_SHEEP
Uncharacterized protein.
    
 0.498
SDK2
Sidekick cell adhesion molecule 2.
    
 0.496
SNED1
Sushi, nidogen and EGF like domains 1.
    
 0.492
PEF1
Penta-EF-hand domain containing 1.
   
 
 0.488
ITGB1BP1
Integrin subunit beta 1 binding protein 1.
      
 0.482
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.