STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (505 aa)    
Predicted Functional Partners:
LRRC30
Uncharacterized protein.
      
 0.769
ALDH1A2
Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.
   
 
 0.657
W5QC58_SHEEP
ANK_REP_REGION domain-containing protein.
    
 0.640
RARS1
Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.590
CYP7B1
Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.
  
   
 0.579
W5Q3L2_SHEEP
SLC12 domain-containing protein.
   
 
 0.578
CYP11A1
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (By similarity). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into [...]
  
 
 0.545
RDH10
Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.539
ELF4
E74 like ETS transcription factor 4.
      
 0.537
W5NPP3_SHEEP
Uncharacterized protein; Belongs to the cytochrome P450 family.
  
 
 0.520
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.