Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CST6Cystatin E/M; Belongs to the cystatin family. (149 aa)    
Predicted Functional Partners:
LGMN
Legumain.
    
 
 0.955
CTSV
Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.
    
 0.792
CYP4X1
Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family.
   
 
 0.653
CTSS
Cathepsin S; Belongs to the peptidase C1 family.
    
 0.625
PRR9
Proline rich 9.
      
 0.622
CST7
Cystatin F.
      
 0.612
PRSS35
Serine protease 35.
      
 0.592
BIRC6
Baculoviral IAP repeat containing 6.
   
 0.584
KRT2.11
IF rod domain-containing protein; Belongs to the intermediate filament family.
     
 0.579
LOR
Uncharacterized protein.
    
 0.557
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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