STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5NTD5_SHEEPDHR-2 domain-containing protein; Belongs to the DOCK family. (141 aa)    
Predicted Functional Partners:
CDC42
Cell division cycle 42.
   
 0.931
ARHGEF16
Rho guanine nucleotide exchange factor 16.
     
 0.539
RAC1
Uncharacterized protein.
   
 0.529
RAC3
Rac family small GTPase 3.
   
 0.529
DOCK2
Dedicator of cytokinesis 2; Belongs to the DOCK family.
   
 
 0.525
RHOJ
Ras homolog family member J.
   
 0.469
W5P784_SHEEP
Uncharacterized protein.
   
 0.465
CDC42BPB
CDC42 binding protein kinase beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
   
 
 0.459
RRP9
Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein.
    
 
 0.455
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
   
 
 0.448
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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