Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DHCR77-dehydrocholesterol reductase. (452 aa)    
Predicted Functional Partners:
DHCR24
24-dehydrocholesterol reductase.
   
 0.995
W5PA17_SHEEP
Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.
   
 0.982
NSDHL
NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.
   
 
 0.966
SQLE
Squalene epoxidase.
   
 
 0.965
CYP51A1
Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.
   
 0.946
LSS
Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.
   
  
 0.940
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 0.939
CYP7A1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
 0.937
SOAT1
O-acyltransferase.
    
 0.914
SOAT2
O-acyltransferase.
    
 0.914
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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