STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5NTI8_SHEEPPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (240 aa)    
Predicted Functional Partners:
KITLG
Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...]
     
 0.756
AGT
Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family.
   
 0.700
TPSB2
Tryptase-2; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily.
  
 
0.526
CPA3
Carboxypeptidase A3.
   
 
 0.524
PRSS27
Serine protease 27; Belongs to the peptidase S1 family.
  
     0.519
W5PB60_SHEEP
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
     0.504
W5PXK1_SHEEP
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
     0.504
W5NXB2_SHEEP
Peptidase S1 domain-containing protein.
  
     0.489
LOC101102413
Uncharacterized protein; Belongs to the peptidase S1 family.
  
 
  0.486
NAPSA
Napsin A aspartic peptidase; Belongs to the peptidase A1 family.
      
 0.480
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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