Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TPX2TPX2 microtubule nucleation factor. (747 aa)    
Predicted Functional Partners:
AURKA
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 0.938
COG5
Component of oligomeric golgi complex 5.
   
 0.877
COG3
Component of oligomeric golgi complex 3.
   
 0.867
COG2
Component of oligomeric golgi complex 2.
   
 0.865
COG1
Component of oligomeric golgi complex 1.
   
 0.857
COG6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
   
 0.852
COG8
Conserved oligomeric Golgi complex subunit 8; Belongs to the COG8 family.
   
 0.847
W5PN40_SHEEP
Uncharacterized protein.
   
  
 0.845
CCNA2
Cyclin A2; Belongs to the cyclin family.
   
    0.767
CKAP2L
Cytoskeleton associated protein 2 like.
   
  
 0.767
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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