STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCNH2Potassium voltage-gated channel subfamily H member 2. (739 aa)    
Predicted Functional Partners:
KCNE5
Potassium voltage-gated channel subfamily E regulatory subunit 5.
     
 0.915
KCND3
Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.
   
 0.908
KCNQ1
Ion_trans domain-containing protein; Belongs to the potassium channel family.
   
 
 0.836
KCNE1
Uncharacterized protein.
    
 0.825
KCNJ8
Potassium voltage-gated channel subfamily J member 8.
      
 0.820
SCN5A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
    
 
 0.800
KCNE2
Potassium voltage-gated channel subfamily E regulatory subunit 2.
    
 0.756
CACNA1C
Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
    
 
 0.713
KCNJ2
Potassium voltage-gated channel subfamily J member 2.
      
 0.703
KCNE3
Potassium voltage-gated channel subfamily E regulatory subunit 3.
     
 0.701
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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