Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
LETM2Leucine zipper and EF-hand containing transmembrane protein 2. (491 aa)    
Predicted Functional Partners:
KCNH6
Potassium voltage-gated channel subfamily H member 6.
      
 0.818
MCU
Mitochondrial calcium uniporter.
      
 0.729
FAM118A
Family with sequence similarity 118 member A.
    
 
 0.692
TMEM39B
Transmembrane protein 39B.
      
 0.659
DNAJC18
DnaJ heat shock protein family (Hsp40) member C18.
   
 
 0.650
RHBDD3
Rhomboid domain containing 3.
      
 0.641
SLC25A51
Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.634
W5NS97_SHEEP
FIP-RBD domain-containing protein.
    
 
 0.591
BRF2
BRF2 RNA polymerase III transcription initiation factor subunit.
      
 0.583
PLD6
Phospholipase D family member 6.
      
 0.581
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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