STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TESTestin; Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity); Belongs to the prickle / espinas / testin family. (421 aa)    
Predicted Functional Partners:
ENAH
ENAH actin regulator.
   
 0.835
IAH1
Isoamyl acetate hydrolyzing esterase 1 (putative).
      
 0.793
VASP
Vasodilator stimulated phosphoprotein.
   
 0.720
LOC101110727
Uncharacterized protein.
   
  
 0.698
F13B
Coagulation factor XIII B chain.
      
 0.643
TTC28
Tetratricopeptide repeat domain 28.
    
 
 0.635
EVL
Enah/Vasp-like.
   
 0.610
CYP3A24
Cytochrome P450 3A24; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
   
  
 0.607
DMPK
DM1 protein kinase.
   
 0.533
STK40
Serine/threonine kinase 40.
      
 0.530
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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