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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZSWIM5Zinc finger SWIM-type containing 5. (990 aa)    
Predicted Functional Partners:
ZSWIM9
Zinc finger SWIM-type containing 9.
      
 0.860
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2.
    
 
 0.807
MBIP
MAP3K12 binding inhibitory protein 1.
      
 0.727
CUL2
Cullin 2; Belongs to the cullin family.
     
 0.636
ZSWIM2
Zinc finger SWIM-type containing 2.
      
 0.537
SLC9A7
Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
      
 0.535
FARP2
FERM, ARH/RhoGEF and pleckstrin domain protein 2.
    
 
 0.525
LPP
LIM domain containing preferred translocation partner in lipoma.
      
 0.524
CDON
Cell adhesion associated, oncogene regulated.
      
 0.512
MAP3K12
Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway.
      
 0.512
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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