SREBF1 protein (Ovis aries) - STRING interaction network

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Score

SREBF1

Sterol regulatory element binding transcription factor 1. (1061 aa)

Predicted Functional Partners:

SCAP

0.967

PPARGC1B

0.937

SREBF2

0.930

KPNB1

0.888

W5Q6U0_SHEEP

0.868

SCD

0.865

ACACA

0.864

FASN

0.850

MBTPS2

0.827

PPARG

0.823

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	FASN	ENSOARP00000000876	ENSOARP00000003118	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	Uncharacterized protein.	0.990
ACACA	PPARG	ENSOARP00000000876	ENSOARP00000017667	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.715
ACACA	SCAP	ENSOARP00000000876	ENSOARP00000004158	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	SREBF chaperone.	0.498
ACACA	SCD	ENSOARP00000000876	ENSOARP00000015742	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...]	0.871
ACACA	SREBF1	ENSOARP00000000876	ENSOARP00000001571	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	Sterol regulatory element binding transcription factor 1.	0.864
ACACA	SREBF2	ENSOARP00000000876	ENSOARP00000020098	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	Sterol regulatory element binding transcription factor 2.	0.565
ACACA	W5Q6U0_SHEEP	ENSOARP00000000876	ENSOARP00000018431	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	Carrier domain-containing protein.	0.912
FASN	ACACA	ENSOARP00000003118	ENSOARP00000000876	Uncharacterized protein.	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	0.990
FASN	PPARG	ENSOARP00000003118	ENSOARP00000017667	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.868
FASN	SCAP	ENSOARP00000003118	ENSOARP00000004158	Uncharacterized protein.	SREBF chaperone.	0.485
FASN	SCD	ENSOARP00000003118	ENSOARP00000015742	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...]	0.939
FASN	SREBF1	ENSOARP00000003118	ENSOARP00000001571	Uncharacterized protein.	Sterol regulatory element binding transcription factor 1.	0.850
FASN	SREBF2	ENSOARP00000003118	ENSOARP00000020098	Uncharacterized protein.	Sterol regulatory element binding transcription factor 2.	0.599
FASN	W5Q6U0_SHEEP	ENSOARP00000003118	ENSOARP00000018431	Uncharacterized protein.	Carrier domain-containing protein.	0.529
KPNB1	SREBF1	ENSOARP00000009086	ENSOARP00000001571	Karyopherin subunit beta 1.	Sterol regulatory element binding transcription factor 1.	0.888
KPNB1	SREBF2	ENSOARP00000009086	ENSOARP00000020098	Karyopherin subunit beta 1.	Sterol regulatory element binding transcription factor 2.	0.944
MBTPS2	SCAP	ENSOARP00000017332	ENSOARP00000004158	Membrane bound transcription factor peptidase, site 2.	SREBF chaperone.	0.407
MBTPS2	SREBF1	ENSOARP00000017332	ENSOARP00000001571	Membrane bound transcription factor peptidase, site 2.	Sterol regulatory element binding transcription factor 1.	0.827
MBTPS2	SREBF2	ENSOARP00000017332	ENSOARP00000020098	Membrane bound transcription factor peptidase, site 2.	Sterol regulatory element binding transcription factor 2.	0.846
PPARG	ACACA	ENSOARP00000017667	ENSOARP00000000876	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.	0.715