STAT3 protein (Ovis aries) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

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[Homology]

Score

STAT3

Signal transducer and activator of transcription. (825 aa)

Predicted Functional Partners:

JAK2

0.999

JAK1

0.997

SRC

0.997

SOCS3

0.996

EP300

0.996

JAK3

0.994

STAT1

0.993

STAT5B

0.993

IL6R

0.986

IL6

0.983

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EP300	STAT1	ENSOARP00000019268	ENSOARP00000014920	E1A binding protein p300.	Signal transducer and activator of transcription.	0.978
EP300	STAT3	ENSOARP00000019268	ENSOARP00000001576	E1A binding protein p300.	Signal transducer and activator of transcription.	0.996
EP300	STAT5B	ENSOARP00000019268	ENSOARP00000020368	E1A binding protein p300.	Signal transducer and activator of transcription.	0.955
IL6	IL6R	ENSOARP00000012891	ENSOARP00000002722	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Interleukin 6 receptor.	0.999
IL6	JAK1	ENSOARP00000012891	ENSOARP00000010851	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.985
IL6	JAK2	ENSOARP00000012891	ENSOARP00000014454	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.986
IL6	JAK3	ENSOARP00000012891	ENSOARP00000015703	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.915
IL6	SOCS3	ENSOARP00000012891	ENSOARP00000000153	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Suppressor of cytokine signaling 3.	0.880
IL6	SRC	ENSOARP00000012891	ENSOARP00000019257	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.718
IL6	STAT1	ENSOARP00000012891	ENSOARP00000014920	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Signal transducer and activator of transcription.	0.870
IL6	STAT3	ENSOARP00000012891	ENSOARP00000001576	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Signal transducer and activator of transcription.	0.983
IL6	STAT5B	ENSOARP00000012891	ENSOARP00000020368	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Signal transducer and activator of transcription.	0.891
IL6R	IL6	ENSOARP00000002722	ENSOARP00000012891	Interleukin 6 receptor.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.999
IL6R	JAK1	ENSOARP00000002722	ENSOARP00000010851	Interleukin 6 receptor.	Tyrosine-protein kinase.	0.966
IL6R	JAK2	ENSOARP00000002722	ENSOARP00000014454	Interleukin 6 receptor.	Tyrosine-protein kinase.	0.971
IL6R	JAK3	ENSOARP00000002722	ENSOARP00000015703	Interleukin 6 receptor.	Tyrosine-protein kinase.	0.903
IL6R	SOCS3	ENSOARP00000002722	ENSOARP00000000153	Interleukin 6 receptor.	Suppressor of cytokine signaling 3.	0.769
IL6R	SRC	ENSOARP00000002722	ENSOARP00000019257	Interleukin 6 receptor.	Tyrosine-protein kinase.	0.922
IL6R	STAT1	ENSOARP00000002722	ENSOARP00000014920	Interleukin 6 receptor.	Signal transducer and activator of transcription.	0.556
IL6R	STAT3	ENSOARP00000002722	ENSOARP00000001576	Interleukin 6 receptor.	Signal transducer and activator of transcription.	0.986