STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIEZO2Piezo-type mechanosensitive ion channel component. (2740 aa)    
Predicted Functional Partners:
TRPV4
Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.707
MCM4
DNA helicase; Belongs to the MCM family.
   
 0.696
TIPIN
TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.
   
 
 0.676
GSE1
Gse1 coiled-coil protein.
      
 0.655
PIK3CD
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.
      
 0.654
TIMELESS
Uncharacterized protein.
    
 
 0.651
CDC45
Cell division cycle 45.
    
 0.649
WDHD1
WD repeat and HMG-box DNA binding protein 1.
   
 
 0.638
CHEK2
Checkpoint kinase 2.
    
 
 0.636
ALKBH4
AlkB homolog 4, lysine demethylase.
      
 0.624
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.