STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ITIH1Inter-alpha-trypsin inhibitor heavy chain 1. (912 aa)    
Predicted Functional Partners:
AMBP
Inter-alpha-trypsin inhibitor; This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.
   
  
 0.863
APOH
Apolipoprotein H.
   
 0.667
ITIH5
Inter-alpha-trypsin inhibitor heavy chain 5.
 
0.617
VCAN
Versican.
   
 0.598
FETUB
Fetuin B.
   
 0.572
HABP4
Hyaluronan binding protein 4.
    
 
 0.567
SERPINA3
SERPIN domain-containing protein; Belongs to the serpin family.
   
 
 0.560
SERPINC1
Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).
   
 
 0.544
SERPINA1
Alpha-1-antiproteinase; Inhibits human leukocyte elastase, pig pancreatic elastase and bovine trypsin on a 1:1 molar basis; Belongs to the serpin family.
   
 
 0.543
SERPINA10
Serpin family A member 10; Belongs to the serpin family.
   
 
 0.541
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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