STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NFATC2IPNuclear factor of activated T cells 2 interacting protein. (324 aa)    
Predicted Functional Partners:
RANBP2
RAN binding protein 2.
   
 0.894
SAE1
SUMO1 activating enzyme subunit 1.
   
 0.823
UBA2
SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.
   
 0.799
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.796
UBE2I
Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.760
RANGAP1
Ran GTPase activating protein 1.
    
 0.741
KCTD2
Potassium channel tetramerization domain containing 2.
   
 0.730
RAD52
RAD52 homolog, DNA repair protein.
    
 0.683
NEDD8
NEDD8 ubiquitin like modifier.
   
 0.666
SENP2
SUMO specific peptidase 2.
   
 0.665
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.