Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DENND4BDENN domain containing 4B. (1431 aa)    
Predicted Functional Partners:
CCDC102A
Coiled-coil domain containing 102A.
      
 0.875
DENND1C
DENN domain containing 1C.
    
 
 0.873
TMEM129
Transmembrane protein 129.
      
 0.854
BMS1
BMS1 ribosome biogenesis factor.
      
 0.792
DENND5B
DENN domain containing 5B.
    
 
0.739
CTU2
Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the CTU2/NCS2 family.
    
 
 0.700
RAB8B
RAB8B, member RAS oncogene family.
    
 0.690
RAB10
Uncharacterized protein.
    
 0.673
AVL9
AVL9 cell migration associated.
      
 0.669
DENND5A
DENN domain containing 5A.
    
 
0.661
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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