W5NU27_SHEEP protein (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

W5NU27_SHEEP

Rho-GAP domain-containing protein. (148 aa)

Predicted Functional Partners:

RHOBTB3

0.711

RHOA

0.592

W5Q4M2_SHEEP

0.592

RHOB

0.592

GTF2E2

0.549

ITGB1BP2

0.538

NEMP1

0.536

RND3

0.514

RND1

0.514

RIOK1

0.509

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GTF2E2	NEMP1	ENSOARP00000011161	ENSOARP00000008290	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Nuclear envelope integral membrane protein 1.	0.649
GTF2E2	RIOK1	ENSOARP00000011161	ENSOARP00000019044	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	0.571
GTF2E2	W5NU27_SHEEP	ENSOARP00000011161	ENSOARP00000001671	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	Rho-GAP domain-containing protein.	0.549
ITGB1BP2	W5NU27_SHEEP	ENSOARP00000018295	ENSOARP00000001671	Integrin subunit beta 1 binding protein 2.	Rho-GAP domain-containing protein.	0.538
NEMP1	GTF2E2	ENSOARP00000008290	ENSOARP00000011161	Nuclear envelope integral membrane protein 1.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.649
NEMP1	RIOK1	ENSOARP00000008290	ENSOARP00000019044	Nuclear envelope integral membrane protein 1.	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	0.556
NEMP1	W5NU27_SHEEP	ENSOARP00000008290	ENSOARP00000001671	Nuclear envelope integral membrane protein 1.	Rho-GAP domain-containing protein.	0.536
RHOA	RND1	ENSOARP00000014865	ENSOARP00000020511	RHOA.	Rho family GTPase 1.	0.938
RHOA	W5NU27_SHEEP	ENSOARP00000014865	ENSOARP00000001671	RHOA.	Rho-GAP domain-containing protein.	0.592
RHOA	W5Q4M2_SHEEP	ENSOARP00000014865	ENSOARP00000017662	RHOA.	Uncharacterized protein.	0.900
RHOB	W5NU27_SHEEP	ENSOARP00000020882	ENSOARP00000001671	Uncharacterized protein.	Rho-GAP domain-containing protein.	0.592
RHOBTB3	W5NU27_SHEEP	ENSOARP00000018679	ENSOARP00000001671	Rho related BTB domain containing 3.	Rho-GAP domain-containing protein.	0.711
RIOK1	GTF2E2	ENSOARP00000019044	ENSOARP00000011161	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.571
RIOK1	NEMP1	ENSOARP00000019044	ENSOARP00000008290	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	Nuclear envelope integral membrane protein 1.	0.556
RIOK1	W5NU27_SHEEP	ENSOARP00000019044	ENSOARP00000001671	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	Rho-GAP domain-containing protein.	0.509
RND1	RHOA	ENSOARP00000020511	ENSOARP00000014865	Rho family GTPase 1.	RHOA.	0.938
RND1	W5NU27_SHEEP	ENSOARP00000020511	ENSOARP00000001671	Rho family GTPase 1.	Rho-GAP domain-containing protein.	0.514
RND1	W5Q4M2_SHEEP	ENSOARP00000020511	ENSOARP00000017662	Rho family GTPase 1.	Uncharacterized protein.	0.937
RND3	W5NU27_SHEEP	ENSOARP00000009900	ENSOARP00000001671	Rho family GTPase 3.	Rho-GAP domain-containing protein.	0.514
W5NU27_SHEEP	GTF2E2	ENSOARP00000001671	ENSOARP00000011161	Rho-GAP domain-containing protein.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.549