IL22 protein (Ovis aries) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

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Score

IL22

Interleukin 22. (190 aa)

Predicted Functional Partners:

IL22RA1

0.998

IL10RB

0.991

CD4

0.969

IL22RA2

0.954

IL23R

0.952

IL26

0.948

IL17A

0.930

IFNAR1

0.908

IL17F

0.896

STAT3

0.887

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	IFNAR1	ENSOARP00000006749	ENSOARP00000014132	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	0.814
CD4	IL17A	ENSOARP00000006749	ENSOARP00000014949	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interleukin-17A.	0.975
CD4	IL17F	ENSOARP00000006749	ENSOARP00000015094	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interleukin 17F.	0.903
CD4	IL22	ENSOARP00000006749	ENSOARP00000001675	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interleukin 22.	0.969
CD4	IL23R	ENSOARP00000006749	ENSOARP00000011882	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interleukin 23 receptor.	0.873
CD4	IL26	ENSOARP00000006749	ENSOARP00000001954	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Interleukin 26.	0.644
CD4	STAT3	ENSOARP00000006749	ENSOARP00000001576	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	Signal transducer and activator of transcription.	0.954
IFNAR1	CD4	ENSOARP00000014132	ENSOARP00000006749	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.814
IFNAR1	IL10RB	ENSOARP00000014132	ENSOARP00000014196	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Interleukin 10 receptor subunit beta.	0.598
IFNAR1	IL22	ENSOARP00000014132	ENSOARP00000001675	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Interleukin 22.	0.908
IFNAR1	IL22RA1	ENSOARP00000014132	ENSOARP00000007273	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Interleukin 22 receptor subunit alpha 1.	0.741
IFNAR1	STAT3	ENSOARP00000014132	ENSOARP00000001576	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Signal transducer and activator of transcription.	0.897
IL10RB	IFNAR1	ENSOARP00000014196	ENSOARP00000014132	Interleukin 10 receptor subunit beta.	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	0.598
IL10RB	IL22	ENSOARP00000014196	ENSOARP00000001675	Interleukin 10 receptor subunit beta.	Interleukin 22.	0.991
IL10RB	IL22RA1	ENSOARP00000014196	ENSOARP00000007273	Interleukin 10 receptor subunit beta.	Interleukin 22 receptor subunit alpha 1.	0.986
IL10RB	IL22RA2	ENSOARP00000014196	ENSOARP00000000478	Interleukin 10 receptor subunit beta.	Interleukin 22 receptor subunit alpha 2.	0.487
IL10RB	IL26	ENSOARP00000014196	ENSOARP00000001954	Interleukin 10 receptor subunit beta.	Interleukin 26.	0.969
IL10RB	STAT3	ENSOARP00000014196	ENSOARP00000001576	Interleukin 10 receptor subunit beta.	Signal transducer and activator of transcription.	0.702
IL17A	CD4	ENSOARP00000014949	ENSOARP00000006749	Interleukin-17A.	T-cell surface glycoprotein CD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.	0.975
IL17A	IL17F	ENSOARP00000014949	ENSOARP00000015094	Interleukin-17A.	Interleukin 17F.	0.991