| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACACA | ACSL1 | ENSOARP00000000876 | ENSOARP00000008176 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Acyl-CoA synthetase long chain family member 1. | 0.841 |
| ACACA | ACSS2 | ENSOARP00000000876 | ENSOARP00000011568 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Acyl-CoA synthetase short chain family member 2. | 0.974 |
| ACACA | DGAT1 | ENSOARP00000000876 | ENSOARP00000015100 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. | 0.715 |
| ACACA | FABP3 | ENSOARP00000000876 | ENSOARP00000001683 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.727 |
| ACACA | FASN | ENSOARP00000000876 | ENSOARP00000003118 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Uncharacterized protein. | 0.990 |
| ACACA | GPAM | ENSOARP00000000876 | ENSOARP00000011769 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Glycerol-3-phosphate acyltransferase, mitochondrial. | 0.736 |
| ACACA | LPIN1 | ENSOARP00000000876 | ENSOARP00000017337 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Lipin 1. | 0.883 |
| ACACA | PLIN2 | ENSOARP00000000876 | ENSOARP00000015248 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Perilipin; Belongs to the perilipin family. | 0.635 |
| ACACA | PPARG | ENSOARP00000000876 | ENSOARP00000017667 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.715 |
| ACACA | W5Q6U0_SHEEP | ENSOARP00000000876 | ENSOARP00000018431 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Carrier domain-containing protein. | 0.912 |
| ACSL1 | ACACA | ENSOARP00000008176 | ENSOARP00000000876 | Acyl-CoA synthetase long chain family member 1. | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | 0.841 |
| ACSL1 | ACSS2 | ENSOARP00000008176 | ENSOARP00000011568 | Acyl-CoA synthetase long chain family member 1. | Acyl-CoA synthetase short chain family member 2. | 0.717 |
| ACSL1 | DGAT1 | ENSOARP00000008176 | ENSOARP00000015100 | Acyl-CoA synthetase long chain family member 1. | Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. | 0.663 |
| ACSL1 | FABP3 | ENSOARP00000008176 | ENSOARP00000001683 | Acyl-CoA synthetase long chain family member 1. | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.702 |
| ACSL1 | FASN | ENSOARP00000008176 | ENSOARP00000003118 | Acyl-CoA synthetase long chain family member 1. | Uncharacterized protein. | 0.977 |
| ACSL1 | GPAM | ENSOARP00000008176 | ENSOARP00000011769 | Acyl-CoA synthetase long chain family member 1. | Glycerol-3-phosphate acyltransferase, mitochondrial. | 0.641 |
| ACSL1 | LPIN1 | ENSOARP00000008176 | ENSOARP00000017337 | Acyl-CoA synthetase long chain family member 1. | Lipin 1. | 0.695 |
| ACSL1 | PLIN2 | ENSOARP00000008176 | ENSOARP00000015248 | Acyl-CoA synthetase long chain family member 1. | Perilipin; Belongs to the perilipin family. | 0.571 |
| ACSL1 | PPARG | ENSOARP00000008176 | ENSOARP00000017667 | Acyl-CoA synthetase long chain family member 1. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.782 |
| ACSL1 | W5Q6U0_SHEEP | ENSOARP00000008176 | ENSOARP00000018431 | Acyl-CoA synthetase long chain family member 1. | Carrier domain-containing protein. | 0.787 |