Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
MLH3MutL homolog 3. (1485 aa)    
Predicted Functional Partners:
MLH1
MutL homolog 1.
    
0.992
MSH4
MutS homolog 4.
  
 0.979
W5P5E4_SHEEP
DNA_MISMATCH_REPAIR_2 domain-containing protein.
  
 0.973
MSH6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 0.923
MSH2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 0.918
MSH3
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 0.911
HFM1
Helicase for meiosis 1.
    
 
 0.911
RNF212B
Ring finger protein 212B.
      
 0.866
PMS1
PMS1 homolog 1, mismatch repair system component.
   
0.823
PMS2
PMS1 homolog 2, mismatch repair system component.
   
0.801
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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