STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PPM1KProtein phosphatase, Mg2+/Mn2+ dependent 1K. (372 aa)    
Predicted Functional Partners:
BCKDHB
Branched chain keto acid dehydrogenase E1 subunit beta.
    
 0.883
DBT
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
    
 0.857
BCKDHA
2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
   
 0.849
PPM1J
Protein phosphatase, Mg2+/Mn2+ dependent 1J.
      
 0.670
NT5DC2
5'-nucleotidase domain containing 2.
      
 0.667
RABEP1
Rabaptin, RAB GTPase binding effector protein 1.
    
 
 0.666
MTMR9
Myotubularin related protein 9.
      
 0.665
PTPN23
ALIX_LYPXL_bnd domain-containing protein.
   
 
 0.660
PLPP6
Phospholipid phosphatase 6.
      
 0.657
NEK8
NIMA related kinase 8.
    
 
 0.614
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.