STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1969 aa)    
Predicted Functional Partners:
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.908
SCN2B
Sodium voltage-gated channel beta subunit 2.
   
 0.897
SCN1B
Sodium voltage-gated channel beta subunit 1.
   
 0.885
TRPM4
Transient receptor potential cation channel subfamily M member 4.
     
 0.777
SCN3B
Sodium voltage-gated channel beta subunit 3.
    
 0.764
SCN4B
Sodium voltage-gated channel beta subunit 4.
    
 0.726
MRGPRD
G_PROTEIN_RECEP_F1_2 domain-containing protein.
     
 0.706
KCNK17
Potassium two pore domain channel subfamily K member 17.
      
 0.684
DOK4
Docking protein 4.
      
 0.653
CACNA2D4
Calcium voltage-gated channel auxiliary subunit alpha2delta 4.
   
 0.618
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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