Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TMEM52Transmembrane protein 52. (183 aa)    
Predicted Functional Partners:
CFAP74
Uncharacterized protein.
      
 0.913
MORN1
MORN repeat containing 1.
      
 0.887
TTC34
Tetratricopeptide repeat domain 34.
  
   
 0.884
LRRC63
Leucine rich repeat containing 63.
      
 0.848
GFOD1
Glucose-fructose oxidoreductase domain containing 1.
      
 0.844
RNF175
Ring finger protein 175.
      
 0.822
SIAH3
E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
      
 0.809
LRCH1
Leucine rich repeats and calponin homology domain containing 1.
      
 0.809
TMTC3
Transmembrane O-mannosyltransferase targeting cadherins 3.
      
 0.769
GABRD
Gamma-aminobutyric acid type A receptor delta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
      
 0.752
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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