Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (637 aa)    
Predicted Functional Partners:
EIF2S1
Eukaryotic translation initiation factor 2 subunit alpha.
   
 0.995
DELE1
DAP3 binding cell death enhancer 1.
    
 0.971
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
  
 
  0.919
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
  
 
 
0.907
IFIT1
Interferon induced protein with tetratricopeptide repeats 1.
  
 
 0.903
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
     
  0.900
EIF2S3
Tr-type G domain-containing protein.
   
 0.841
EIF2S2
Eukaryotic translation initiation factor 2 subunit beta.
   
 0.778
EIF2B1
Eukaryotic translation initiation factor 2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family.
   
 
 0.775
EIF2A
Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
   
 
 0.750
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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