Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
CRYBA4Crystallin beta A4; Belongs to the beta/gamma-crystallin family. (304 aa)    
Predicted Functional Partners:
GRIFIN
Galectin.
   
  
 0.778
CRYBB2
Crystallin beta B2; Belongs to the beta/gamma-crystallin family.
   
 
 0.774
LGSN
Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family.
      
 0.766
BFSP1
Beaded filament structural protein 1; Belongs to the intermediate filament family.
      
 0.699
CRYAA
Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
   
 
 0.696
CRYBB3
Beta B3 crystallin; Belongs to the beta/gamma-crystallin family.
   
 
 0.691
GJA3
Gap junction alpha-3 protein.
  
   
 0.622
CEP76
Centrosomal protein 76.
    
   0.609
PITX3
Homeobox protein.
      
 0.567
GNB2
G protein subunit beta 2.
      
 0.537
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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