STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5NUE0_SHEEPUbiquitin carboxyl-terminal hydrolase. (487 aa)    
Predicted Functional Partners:
ASXL2
ASXL transcriptional regulator 2.
    
 0.945
BARD1
BRCA1 associated RING domain 1.
    
 0.913
PSMD4
Proteasome 26S non-ATPase subunit 4.
    
 0.908
PSMD8
Proteasome 26S subunit, non-ATPase 8.
   
 0.905
ADRM1
Adhesion regulating molecule 1.
   
 0.905
PSMA1
Proteasome subunit alpha type.
   
 0.893
PSMD11
Proteasome 26S subunit, non-ATPase 11.
   
 0.892
PSMD7
Proteasome 26S subunit, non-ATPase 7.
   
 0.891
PSMD12
Proteasome 26S subunit, non-ATPase 12.
   
 0.889
PSMD2
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
   
 0.888
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.