Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LCN8Lipocalin 8; Belongs to the calycin superfamily. Lipocalin family. (178 aa)    
Predicted Functional Partners:
W5NQC4_SHEEP
Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.832
W5NS55_SHEEP
Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.831
CST11
Cystatin domain-containing protein.
   
  
 0.812
W5P4T6_SHEEP
Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.775
AQP9
Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.774
AQP1
Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.697
AQP11
Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
      
 0.675
LCN1
Lipocalin 1; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.672
DEFB129
Defensin beta 129.
      
 0.665
DEFB127
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.633
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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