STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
USP42Ubiquitin specific peptidase 42; Belongs to the peptidase C19 family. (1325 aa)    
Predicted Functional Partners:
SUDS3
SDS3 homolog, SIN3A corepressor complex component.
    
 0.623
ANKRD61
Ankyrin repeat domain 61.
    
 
 0.614
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.578
OTUD5
OTU deubiquitinase 5.
      
 0.566
RCE1
Ras converting CAAX endopeptidase 1.
     
 0.544
TMTC2
Transmembrane O-mannosyltransferase targeting cadherins 2.
   
  
 0.544
MKRN2
Makorin ring finger protein 2.
      
 0.535
OTUD4
OTU deubiquitinase 4.
      
 0.521
USP25
Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family.
      
 0.521
USP53
Ubiquitin specific peptidase 53.
      
 0.521
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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