STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CATHL3Cathelicidin-3; Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms (By similarity); Belongs to the cathelicidin family. (190 aa)    
Predicted Functional Partners:
CATHL2
Cathelicidin-2; Binds to the lipid A moiety of bacterial lipipolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Potent antimicrobial activity (By similarity); Belongs to the cathelicidin family.
  
 
0.955
LOC101112427
CAP18_C domain-containing protein.
  
 
0.940
NFKB1
Nuclear factor kappa B subunit 1.
   
 
 0.912
RELA
RELA proto-oncogene, NF-kB subunit.
   
 
 0.903
W5P1Y8_SHEEP
Uncharacterized protein.
  
 
 
0.698
SC52_SHEEP
Cathelin-related peptide SC5; Broad spectrum bactericidal agent.
  
 
 
0.688
LTF
Uncharacterized protein; Belongs to the transferrin family.
   
 
 0.627
LCN2
Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.567
S100A12
Protein S100; Belongs to the S-100 family.
   
 
 0.562
DYA
Ig-like domain-containing protein; Belongs to the MHC class II family.
   
 
 0.556
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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