W5NUQ9_SHEEP protein (Ovis aries) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

W5NUQ9_SHEEP

BRCT domain-containing protein. (212 aa)

Predicted Functional Partners:

PAXIP1

0.953

RIF1

0.929

TP53BP1

0.892

PAGR1

0.879

RBBP5

0.833

ASH2L

0.816

SLF1

0.815

NCOA6

0.813

SMC6

0.808

ATM

0.800

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASH2L	NCOA6	ENSOARP00000001254	ENSOARP00000011120	ASH2 like, histone lysine methyltransferase complex subunit.	Nuclear receptor coactivator 6.	0.972
ASH2L	PAGR1	ENSOARP00000001254	ENSOARP00000005848	ASH2 like, histone lysine methyltransferase complex subunit.	PAXIP1 associated glutamate rich protein 1.	0.805
ASH2L	PAXIP1	ENSOARP00000001254	ENSOARP00000006970	ASH2 like, histone lysine methyltransferase complex subunit.	Uncharacterized protein.	0.800
ASH2L	RBBP5	ENSOARP00000001254	ENSOARP00000003678	ASH2 like, histone lysine methyltransferase complex subunit.	RB binding protein 5, histone lysine methyltransferase complex subunit.	0.999
ASH2L	W5NUQ9_SHEEP	ENSOARP00000001254	ENSOARP00000001903	ASH2 like, histone lysine methyltransferase complex subunit.	BRCT domain-containing protein.	0.816
ATM	PAXIP1	ENSOARP00000012764	ENSOARP00000006970	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.790
ATM	RIF1	ENSOARP00000012764	ENSOARP00000009595	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication timing regulatory factor 1.	0.831
ATM	SLF1	ENSOARP00000012764	ENSOARP00000018022	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMC5-SMC6 complex localization factor 1.	0.838
ATM	TP53BP1	ENSOARP00000012764	ENSOARP00000010891	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein p53 binding protein 1.	0.972
ATM	W5NUQ9_SHEEP	ENSOARP00000012764	ENSOARP00000001903	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCT domain-containing protein.	0.800
NCOA6	ASH2L	ENSOARP00000011120	ENSOARP00000001254	Nuclear receptor coactivator 6.	ASH2 like, histone lysine methyltransferase complex subunit.	0.972
NCOA6	PAGR1	ENSOARP00000011120	ENSOARP00000005848	Nuclear receptor coactivator 6.	PAXIP1 associated glutamate rich protein 1.	0.841
NCOA6	PAXIP1	ENSOARP00000011120	ENSOARP00000006970	Nuclear receptor coactivator 6.	Uncharacterized protein.	0.751
NCOA6	RBBP5	ENSOARP00000011120	ENSOARP00000003678	Nuclear receptor coactivator 6.	RB binding protein 5, histone lysine methyltransferase complex subunit.	0.968
NCOA6	W5NUQ9_SHEEP	ENSOARP00000011120	ENSOARP00000001903	Nuclear receptor coactivator 6.	BRCT domain-containing protein.	0.813
PAGR1	ASH2L	ENSOARP00000005848	ENSOARP00000001254	PAXIP1 associated glutamate rich protein 1.	ASH2 like, histone lysine methyltransferase complex subunit.	0.805
PAGR1	NCOA6	ENSOARP00000005848	ENSOARP00000011120	PAXIP1 associated glutamate rich protein 1.	Nuclear receptor coactivator 6.	0.841
PAGR1	PAXIP1	ENSOARP00000005848	ENSOARP00000006970	PAXIP1 associated glutamate rich protein 1.	Uncharacterized protein.	0.763
PAGR1	RBBP5	ENSOARP00000005848	ENSOARP00000003678	PAXIP1 associated glutamate rich protein 1.	RB binding protein 5, histone lysine methyltransferase complex subunit.	0.813
PAGR1	W5NUQ9_SHEEP	ENSOARP00000005848	ENSOARP00000001903	PAXIP1 associated glutamate rich protein 1.	BRCT domain-containing protein.	0.879