STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADAM9ADAM metallopeptidase domain 9. (821 aa)    
Predicted Functional Partners:
PLEKHA2
Pleckstrin homology domain containing A2.
      
 0.660
AVL9
AVL9 cell migration associated.
      
 0.634
APH1B
Aph-1 homolog B, gamma-secretase subunit.
      
 0.532
HTRA4
HtrA serine peptidase 4.
      
 0.531
APP
Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]
     
 0.501
CCDC66
Coiled-coil domain containing 66.
      
 0.499
ADAM17
ADAM metallopeptidase domain 17.
      
0.495
PRCD
Photoreceptor disc component.
      
 0.480
KLHL21
Kelch like family member 21.
      
 0.470
NCSTN
Nicastrin.
      
 0.467
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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