STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPIRE1Spire type actin nucleation factor 1. (633 aa)    
Predicted Functional Partners:
FMN1
Formin 1.
    
 0.833
GRAP2
GRB2 related adaptor protein 2.
   
 0.821
CAAP1
Caspase activity and apoptosis inhibitor 1.
      
 0.773
W5NYX9_SHEEP
FH2 domain-containing protein.
    
 0.749
W5QFE0_SHEEP
Uncharacterized protein.
    
 0.749
GRB2
Growth factor receptor bound protein 2.
   
 0.718
GREB1L
GREB1 like retinoic acid receptor coactivator.
      
 0.713
DAAM2
Dishevelled associated activator of morphogenesis 2.
    
 0.700
JMY
Junction mediating and regulatory protein, p53 cofactor.
   
 0.655
SNX13
Sorting nexin 13.
    
 
 0.615
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.