Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CYTH3Cytohesin 3. (404 aa)    
Predicted Functional Partners:
CYTIP
Cytohesin 1 interacting protein.
   
 
 0.833
ARF6
ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.
    
 0.780
CYTH2
Uncharacterized protein.
   
  0.744
INAVA
Innate immunity activator.
    
 
 0.720
ARHGAP21
Rho GTPase activating protein 21.
      
 0.698
CNKSR1
Connector enhancer of kinase suppressor of Ras 1.
   
 
 0.677
ITGB2
Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...]
   
 
 0.642
ARF1
ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.
   
 0.631
CCDC120
Coiled-coil domain containing 120.
    
 
 0.607
PTAFR
Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.577
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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