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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARHGAP26Rho GTPase activating protein 26. (816 aa)    
Predicted Functional Partners:
LGI1
Leucine rich glioma inactivated 1.
      
 0.890
DNER
Delta/notch like EGF repeat containing.
      
 0.833
ZIC4
Zic family member 4.
    
 
 0.812
W5PJN7_SHEEP
WH1 domain-containing protein.
   
  
 0.796
AMPH
Amphiphysin.
      
 0.733
ITPR1
Inositol 1,4,5-trisphosphate receptor type 1.
      
 0.724
PNMA2
PNMA family member 2.
      
 0.689
BIN1-2
Uncharacterized protein.
      
 0.656
RCVRN
Recoverin.
      
 0.645
AQP4
Aquaporin-4 M1 isoform; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.633
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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